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1

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Ning Xi, Yunxin Bo, Elizabeth M. Doherty, Christopher Fotsch, Narender R. Gavva, Nianhe Han, Randall W. Hungate, Lana Klionsky, Qingyian Liu, Rami Tamir, Shimin Xu, James J.S. Treanor, Mark H. Norman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 171 KB

english, 2005

2

Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists

Markian M. Stec, Yunxin Bo, Partha P. Chakrabarti, Lillian Liao, Mqhele Ncube, Nuria Tamayo, Rami Tamir, Narender R. Gavva, James J.S. Treanor, Mark H. Norman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 202 KB

english, 2008

3

Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists

Vijay K. Gore, Vu V. Ma, Rami Tamir, Narender R. Gavva, James J.S. Treanor, Mark H. Norman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 237 KB

english, 2007

4

Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility

Xianghong Wang, Partha P. Chakrabarti, Vassil I. Ognyanov, Liping H. Pettus, Rami Tamir, Helming Tan, Phi Tang, James J.S. Treanor, Narender R. Gavva, Mark H. Norman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 191 KB

english, 2007

5

4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties

Elizabeth M. Doherty, Daniel Retz, Narender R. Gavva, Rami Tamir, James J.S. Treanor, Mark H. Norman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 277 KB

english, 2008

6

Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia

Vemuganti L. Raghavendra Rao, Kellie K. Bowen, Vinay K. Dhodda, Guoqing Song, James L. Franklin, Narender R. Gavva, Robert J. Dempsey

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 551 KB

english, 2002

7

Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells

Daftari, Pratibha, Gavva, Narender R, Shen, C-K James

Journal:

Year:

1999

Language:

english

File:

PDF, 255 KB

english, 1999

8

The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors

Alexandre A. Steiner, Alla Y. Molchanova, M. Devrim Dogan, Shreya Patel, Erika Pétervári, Márta Balaskó, Samuel P. Wanner, Justin Eales, Daniela L. Oliveira, Narender R. Gavva, M. Camila Almeida, Mikl

Journal:

The Journal of Physiology

Year:

2011

Language:

english

File:

PDF, 650 KB

english, 2011

9

Cadmium induced potassium efflux fromScenedesmus quadricauda

Gavva Narender Reddy, M. N. V. Prasad

Journal:

Bulletin of Environmental Contamination and Toxicology

Year:

1992

Language:

english

File:

PDF, 265 KB

english, 1992

10

Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

Gilbert Y. Wong, Narender R. Gavva

Journal:

Brain Research Reviews

Year:

2009

Language:

english

File:

PDF, 413 KB

english, 2009

11

Novel Vanilloid Receptor-1 Antagonists: 3. The Identification of a Second-Generation Clinical Candidate with Improved Physicochemical and Pharmacokinetic Properties

Wang, Hui-Ling, Katon, Jodie, Balan, Chenera, Bannon, Anthony W., Bernard, Charles, Doherty, Elizabeth M., Dominguez, Celia, Gavva, Narender R., Gore, Vijay, Ma, Vu

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 267 KB

english, 2007

12

NAPP2, a Peroxisomal Membrane Protein, Is Also a Transcriptional Corepressor

Narender R. Gavva, Shau-Ching Wen, Pratibha Daftari, Mariko Moniwa, Wen-Ming Yang, Lan-Ping Teresa Yang-Feng, Edward Seto, James R. Davie, Che-Kun James Shen

Journal:

Year:

2002

Language:

english

File:

PDF, 361 KB

english, 2002

13

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

Narender R. Gavva, James J.S. Treanor, Andras Garami, Liang Fang, Sekhar Surapaneni, Anna Akrami, Francisco Alvarez, Annette Bak, Mary Darling, Anu Gore, Graham R. Jang, James P. Kesslak, Liyun Ni, Ma

Journal:

Year:

2008

Language:

english

File:

PDF, 186 KB

english, 2008

14

The TRPV1 receptor and nociception

David C. Immke, Narender R. Gavva

Journal:

Seminars in Cell & Developmental Biology

Year:

2006

Language:

english

File:

PDF, 465 KB

english, 2006

15

Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1

Narender R. Gavva

Journal:

Trends in Pharmacological Sciences

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

16

Human ITCH Is a Coregulator of the Hematopoietic Transcription Factor NF-E2

Xin Chen, Shau-ching Wen, Michiko N. Fukuda, Narender R. Gavva, Duen-wei Hsu, Tomoya O. Akama, Teresa Yang-Feng, C.K.James Shen

Journal:

Year:

2001

Language:

english

File:

PDF, 271 KB

english, 2001

17

Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans -Cinnamides †

Norman, Mark H., Zhu, Jiawang, Fotsch, Christopher, Bo, Yunxin, Chen, Ning, Chakrabarti, Partha, Doherty, Elizabeth M., Gavva, Narender R., Nishimura, Nobuko, Nixey, Thomas, Ognyanov, Vassil I., Rzasa

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 484 KB

english, 2007

18

Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N -Aryl Cinnamides

Doherty, Elizabeth M., Fotsch, Christopher, Bo, Yunxin, Chakrabarti, Partha P., Chen, Ning, Gavva, Narender, Han, Nianhe, Kelly, Michael G., Kincaid, John, Klionsky, Lana, Liu, Qingyian, Ognyanov, Vas

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 321 KB

english, 2005

19

Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Doherty, Elizabeth M., Fotsch, Christopher, Bannon, Anthony W., Bo, Yunxin, Chen, Ning, Dominguez, Celia, Falsey, James, Gavva, Narender R., Katon, Jodie, Nixey, Thomas, Ognyanov, Vassil I., Pettus, L

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 280 KB

english, 2007

20

Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation

Narender R Gavva, Carl Davis, Sonya G Lehto, Sara Rao, Weiya Wang…

Journal:

Year:

2012

Language:

english

File:

PDF, 375 KB

english, 2012

21

Characterization of Cadmium Binding Protein from Scenedesmus quadricauda and Cd Toxicity Reversal by Phytochelatin Constituting Amino Acids and Citrate

Reddy, Gavva Narender, Prasad, M.N.V.

Journal:

Journal of Plant Physiology

Year:

1992

Language:

english

File:

PDF, 693 KB

english, 1992

22

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

Tamayo, Nuria, Liao, Hongyu, Stec, Markian M., Wang, Xianghong, Chakrabarti, Partha, Retz, Dan, Doherty, Elizabeth M., Surapaneni, Sekhar, Tamir, Rami, Bannon, Anthony W., Gavva, Narender R., Norman,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 336 KB

english, 2008

23

AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

Lehto, Sonya G., Weyer, Andy D., Zhang, Maosheng, Youngblood, Beth D., Wang, Judy, Wang, Weiya, Kerstein, Patrick C., Davis, Carl, Wild, Kenneth D., Stucky, Cheryl L., Gavva, Narender R.

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2015

Language:

english

File:

PDF, 494 KB

english, 2015

24

The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons

Leffler, Andreas, Fischer, Michael J., Rehner, Dietlinde, Kienel, Stephanie, Kistner, Katrin, Sauer, Susanne K., Gavva, Narender R., Reeh, Peter W., Nau, Carla

Journal:

Journal of Clinical Investigation

Year:

2008

Language:

english

File:

PDF, 1.97 MB

english, 2008

25

Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory

Wanner, Samuel P., Garami, Andras, Pakai, Eszter, Oliveira, Daniela L., Gavva, Narender R., Coimbra, Cândido C., Romanovsky, Andrej A.

Journal:

Year:

2012

Language:

english

File:

PDF, 786 KB

english, 2012

26

TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds’ pharmacological profiles, in-vivo targets, thermoeffectors recruited, and implications for drug development

Garami, Andras, Pakai, Eszter, McDonald, Heath A., Reilly, Regina M., Gomtsyan, Arthur, Corrigan, Joshua J., Pinter, Erika, Zhu, Dawn X. D., Lehto, Sonya G., Gavva, Narender R., Kym, Philip R., Romano

Journal:

Acta Physiologica

Year:

2018

Language:

english

File:

PDF, 1.16 MB

english, 2018

27

Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation

Miller, Silke, Rao, Sara, Wang, Weiya, Liu, Hantao, Wang, Judy, Gavva, Narender R., McKemy, David D.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

28

Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans

Gavva, Narender R., Sandrock, Robert, Arnold, Gregory E., Davis, Michael, Lamas, Edwin, Lindvay, Chris, Li, Chi-Ming, Smith, Brian, Backonja, Miroslav, Gabriel, Kristin, Vargas, Gabriel

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.55 MB

english, 2019

29

Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans

Gavva, Narender R., Sandrock, Robert, Arnold, Gregory E., Davis, Michael, Lamas, Edwin, Lindvay, Chris, Li, Chi-Ming, Smith, Brian, Backonja, Miroslav, Gabriel, Kristin, Vargas, Gabriel

Journal:

Scientific Reports

Year:

2019

File:

PDF, 1.55 MB

2019

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